In Austin, Texas, girlfriends Julia Lucai, Arlene, Shanna and Lanna Frank meet in a bar to drink, smoke and make out with their boyfriends before traveling alone to Lake LBJ to spend the weekend together. They meet the former Hollywood stunt man, Mike, who takes Pam out in his "death-proof" stunt car. Pam soon discovers Mike s secret. Fourteen months later, Mike turns up in Lebanon, Tennessee. Abernathy "Abbie" works in the make-up department on a film set. Zoл Bell, Kim and Lee are all chased by him but the girls are tough and decide to pay-back the attack.

After an experimental bio-nerve gas is accidentally released at a remote U.S. military base in Texas, those exposed to the gas turn into flesh-eating, mutating zombies out to kill. An assortment of various people who include stripper Cherry, her shady mechanic ex-boyfriend Wray, a strong-willed doctor, the local sheriff, and an assortment of various people must join forces to survive the night as the so-called "sickos" threaten to take over the whole town and the world.